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Image Search Results
Journal: Kidney international
Article Title: Targeted reduction of advanced glycation improves renal function in obesity.
doi: 10.1038/ki.2011.57
Figure Lengend Snippet: Figure 2 | Murine renal and biochemical parameters at study completion. Groups of mice were followed for 16 weeks. (a) Urinary albumin excretion rate (AER) over 24 h measured by enzyme-linked immunosorbent assay (ELISA). (b) Creatinine clearance (CrCl) as determined by high-performance liquid chromatography (HPLC) following correction for body surface area. (c–e) N-Carboxymethyllysine (CML) analyzed by ELISA in plasma (c), dietary CML consumption over 24 h (d), and kidney cortex protein (e). (f) CML immunohistochemistry staining on paraffin-fixed kidney sections from (A) lean low advanced glycation end-product (AGE), (B) obese, (C) obese alagebrium (ALA), and (D) obese RAGE–/–. Obese (high AGE/high-fat diet), ALA (AGE-lowering therapy, alagebrium chloride 1 mg/kg/day), and RAGE–/– (RAGE deletion). Data for AER were logarithmically transformed as these were not normally distributed. Other data are presented as mean±s.d. *Po0.05 vs lean low AGE, **Po0.01 vs lean low AGE, ***Po0.001 vs lean low AGE, wPo0.05 vs obese.
Article Snippet: Albumin excretion rate was assessed using a
Techniques: Enzyme-linked Immunosorbent Assay, High Performance Liquid Chromatography, Clinical Proteomics, Immunohistochemistry, Staining, Transformation Assay